Methylation profile in penile carcinoma reveals unique signature relative to surround tissue and HPV status
نویسندگان
چکیده
Background Penile carcinoma (PeCa) is an important public health problem in poor and developing countries. Despite the unpredictable behavior and aggressive treatment, there are few data on molecular and epigenetic mechanisms reported in PeCa. The aim of this study was to identify epigenetic profile in tumors and surrounding tissue as well as to identify molecular markers in PeCa, according to the Papillomavirus (HPV) infection.
منابع مشابه
Epigenetics markers of metastasis and HPV-induced tumorigenesis in penile cancer.
PURPOSE Penile cancer is a rare malignancy in the developed world with just more than 1,600 new cases diagnosed in the United States per year; however, the incidence is much higher in developing countries. Although HPV is known to contribute to tumorigenesis, little is known about the genetic or epigenetic alterations defining penile cancer. EXPERIMENTAL DESIGN Using high-density genome-wide ...
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013